Skip to contents


To install MVMR directly from the GitHub repository, first make sure you have the remotes package installed:


Then the MVMR package can be installed using:

install_github("WSpiller/MVMR", build_opts = c("--no-resave-data", "--no-manual"), build_vignettes = TRUE)

To update the package just run the remotes::install_github("WSpiller/MVMR", build_opts = c("--no-resave-data", "--no-manual"), build_vignettes = TRUE) command again.


We have written the MVMR R package to perform multivariable Mendelian randomization analyses, including heterogeneity statistics for assessing instrument strength and validity. The package accommodates any number of exposures greater than 1, and is currently includes a range of functions for estimating causal effects, as well as assessing conditional instrument strength and pleiotropic bias. For a detailed description regarding each function, please install the package and input vignette("MVMR")


This project is licensed under GNU GPL v3.