Raw multivariable MR summary data using lipid fractions as exposures and systolic blood pressure as an outcome.

A dataset containing summary data on 145 genetic variants associated with either low-density lipoprotein (LDL), high-density lipoprotein (HDL), or triglycerides. Data includes variant rsid numbers, associations with each lipid fraction, the associations between genetic variants and systolic blood pressure (SBP), and corresponding standard errors.

Usage

rawdat_rmvmr

Format

A data frame with 145 rows and 9 variables. Specifically this includes the following information:

snp

The identification number for each variant

ldl_beta

The association estimate for the genetic variant obtained by regressing LDL-C upon the genetic variant

hdl_beta

The association estimate obtained by regressing HDL-C upon the genetic variant

tg_beta

The association estimate obtained by regressing triglycerides upon the genetic variant

sbp_beta

The association estimate for SBP obtained by regressing SBP upon the genetic variant

ldl_se

The standard error corresponding to association estimate ldl_beta

hdl_se

The standard error corresponding to association estimate hdl_beta

tg_se

The standard error corresponding to association estimate tg_beta

sbp_se

The standard error corresponding to association estimate sbp_beta

Source

• http://www.mrbase.org/

• https://www.nature.com/articles/ng.2797

• https://www.nature.com/articles/ng.3768

Details

rawdat_rmvmr

Author

Wes Spiller; Eleanor Sanderson; Jack Bowden.

Examples

head(rawdat_rmvmr)
#>          snp ldl_beta hdl_beta tg_beta    sbp_beta ldl_se hdl_se  tg_se
#> 1 rs10019888  -0.0270   0.0182  0.0228 -0.00426935 0.0046 0.0050 0.0045
#> 2 rs10468017   0.1179   0.0020  0.0379  0.00110389 0.0038 0.0042 0.0039
#> 3  rs1047891  -0.0269   0.0079  0.0000 -0.01317370 0.0039 0.0042 0.0038
#> 4 rs10490626   0.0081  -0.0508  0.0085 -0.00111303 0.0064 0.0069 0.0062
#> 5 rs10761762   0.0191   0.0103 -0.0270 -0.00854986 0.0034 0.0036 0.0033
#> 6 rs10832962   0.0043   0.0320  0.0109  0.00472509 0.0038 0.0040 0.0037
#>       sbp_se
#> 1 0.00280123
#> 2 0.00227690
#> 3 0.00222743
#> 4 0.00374264
#> 5 0.00207701
#> 6 0.00237133